Azathioprine hypersensitivity

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Hypersensitivity to azathioprine in myasthenia gravis.

A patient with myasthenia gravis is described who exhibited hypersensitivity including an apparent acute exacerbation of the underlying disorder when treated with azathioprine. 6-mercaptoprine (6-MP) also produced hypersensitivity which, in contrast, did not manifest as a myasthenic exacerbation.

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Azathioprine Hypersensitivity Syndrome: Two Cases of Febrile Neutrophilic Dermatosis Induced by Azathioprine

BACKGROUND Azathioprine is an immunosuppressive agent used in the treatment of immune-mediated diseases. Azathioprine hypersensitivity syndrome is a rare adverse reaction occurring a few days to weeks after the administration of azathioprine. CASE 1 A 36-year-old male with ulcerative colitis presented with erythematous plaques, pustules and erosions on the lower back, buttocks and thighs asso...

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Leucocytoclastic vasculitis in a patient with azathioprine hypersensitivity.

We report the case of a 77-year-old man admitted nine days after being commenced on azathioprine with symptoms initially thought to be secondary to sepsis but in fact due to azathioprine hypersensitivity. He developed histologically proven cutaneous leucocytoclastic vasculitis following the re-introduction of azathioprine. We review the literature concerning adverse reactions to azathioprine an...

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Azathioprine-Induced Hypersensitivity Reaction Presenting as Erythema Nodosum.

Hypersensitivity reactions to drugs have a very varied clinical spectrum and can present different types of skin lesion, including erythema nodosum. A 44-year-old woman with no known drug allergies, diagnosed with Crohn disease 2 years earlier, had started treatment with azathioprine (AZT) 3 weeks prior to consultation because of laboratory and radiological signs of progression of her Crohn dis...

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Hypersensitivity to azathioprine in a patient with Crohn's disease: a case report.

Azathioprine (AZA) is commonly used in inflammatory bowel disease and many other medical diseases. The most common adverse events of AZA include gastrointestinal effects, hepatotoxicity, myelotoxicity and pancreatitis.

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 2001

ISSN: 0003-4967

DOI: 10.1136/ard.60.7.719a